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Alzheimer's Disease

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Articles published in
J Biol Chem
    June 2022
  1. ZWIERZCHOWSKI-ZARATE AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, et al
    RNA induces unique tau strains and stabilizes Alzheimer's disease seeds.
    J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132.
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  2. KOLAY S, Vega AR, Dodd DA, Perez VA, et al
    The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification.
    J Biol Chem. 2022;298:102014.
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  3. TABASSUM Z, Tseng JH, Isemann C, Tian X, et al
    Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.
    J Biol Chem. 2022;298:101977.
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  4. HITSCHLER L, Lang T
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10.
    J Biol Chem. 2022;298:101911.
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  5. TACHIDA Y, Miura S, Muto Y, Takuwa H, et al
    Endothelial expression of human amyloid precursor protein leads to amyloid beta in the blood and induces cerebral amyloid angiopathy in knock-in mice.
    J Biol Chem. 2022;298:101880.
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    May 2022
  6. LIANG R, Tian Y, Viles JH
    Cross-seeding of wild-type Amyloid-beta with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's Disease.
    J Biol Chem. 2022 May 25:102071. doi: 10.1016/j.jbc.2022.102071.
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  7. KOMATSU A, Iida I, Nasu Y, Ito G, et al
    Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
    J Biol Chem. 2022;298:101933.
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    April 2022
  8. GONZALEZ-GIL A, Porell RN, Fernandes SM, Maenpaa E, et al
    Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.
    J Biol Chem. 2022 Apr 19:101960. doi: 10.1016/j.jbc.2022.101960.
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    March 2022
  9. ZHANG S, Bai P, Lei D, Liang Y, et al
    Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer's Disease-Related Neuropathology in Cell Models.
    J Biol Chem. 2022 Mar 3:101794. doi: 10.1016/j.jbc.2022.101794.
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  10. NEDAEI H, Rezaei-Ghaleh N, Giller K, Becker S, et al
    The calcium-free form of atorvastatin inhibits amyloid-beta(1-42) aggregation in vitro.
    J Biol Chem. 2022;298:101662.
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    February 2022
  11. PUANGMALAI N, Sengupta U, Bhatt N, Gaikwad S, et al
    Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2022 Feb 21:101766. doi: 10.1016/j.jbc.2022.101766.
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  12. AHMED R, Huang J, Lifshitz R, Martinez Pomier K, et al
    Structural determinants of the interactions of catechins with Abeta oligomers and lipid membranes.
    J Biol Chem. 2022;298:101502.
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    January 2022
  13. SHOBO A, James N, Dai D, Rontgen A, et al
    The amyloid-beta1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution.
    J Biol Chem. 2022;298:101483.
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  14. ACOSTA DM, Mancinelli C, Bracken C, Eliezer D, et al
    Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
    J Biol Chem. 2022;298:101442.
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    November 2021
  15. IRIZARRY BA, Davis J, Zhu X, Boon BDC, et al
    Human cerebral vascular amyloid contains both antiparallel and parallel in-register Abeta40 fibrils.
    J Biol Chem. 2021;297:101259.
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    October 2021
  16. DAI B, Zhong T, Chen ZX, Chen W, et al
    Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
    J Biol Chem. 2021;297:101222.
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  17. ISMAEL S, Sindi G, Colvin RA, Lee D, et al
    Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture.
    J Biol Chem. 2021;297:101108.
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    September 2021
  18. LIU H, Kim C, Haldiman T, Sigurdson CJ, et al
    Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.
    J Biol Chem. 2021 Sep 29:101267. doi: 10.1016/j.jbc.2021.101267.
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  19. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
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  20. YIN T, Yao W, Norris KA, D'Adamio L, et al
    A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
    J Biol Chem. 2021;297:101089.
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  21. WEISMILLER HA, Holub TJ, Krzesinski BJ, Margittai M, et al
    A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly.
    J Biol Chem. 2021;297:101021.
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    August 2021
  22. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
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    July 2021
  23. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
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  24. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
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  25. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
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    May 2021
  26. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
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    April 2021
  27. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
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    February 2021
  28. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
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    January 2021
  29. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
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  30. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
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  31. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
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  32. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
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  33. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
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  34. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
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  35. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
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  36. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
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  37. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
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  38. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
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  39. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
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    December 2020
  40. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
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  41. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
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    November 2020
  42. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
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  43. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
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  44. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
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    October 2020
  45. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
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  46. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
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  47. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
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  48. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
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    September 2020
  49. MORI T, Koyama N, Yokoo T, Segawa T, et al
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
    J Biol Chem. 2020 Sep 10. pii: RA119.012330. doi: 10.1074/jbc.RA119.012330.
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  50. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
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    August 2020
  51. SHIMONAKA S, Matsumoto SE, Elahi M, Ishiguro K, et al
    Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
    J Biol Chem. 2020 Aug 5. pii: RA120.013271. doi: 10.1074/jbc.RA120.013271.
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    July 2020
  52. KATSIKOUDI A, Ficulle E, Cavallini A, Sharman G, et al
    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
    J Biol Chem. 2020 Jul 22. pii: RA120.013325. doi: 10.1074/jbc.RA120.013325.
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  53. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
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  54. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
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  55. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
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    June 2020
  56. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
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    May 2020
  57. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
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  58. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
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  59. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
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    April 2020
  60. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
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    March 2020
  61. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
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  62. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
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    January 2020
  63. XIAO Y, Matsuda I, Inoue M, Sasahara T, et al
    NMR-based site-resolved profiling of beta-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.
    J Biol Chem. 2020;295:458-467.
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    September 2019
  64. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
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    August 2019
  65. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
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    July 2019
  66. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
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  67. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
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  68. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
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    June 2019
  69. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
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    May 2019
  70. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
    >> Share

  71. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
    >> Share

    April 2019
  72. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
    >> Share

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