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Articles published in
J Biol Chem
    September 2021
  1. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
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    August 2021
  2. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
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    July 2021
  3. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
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  4. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
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  5. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
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    May 2021
  6. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
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    April 2021
  7. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
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    February 2021
  8. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
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    January 2021
  9. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
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  10. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
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  11. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
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  12. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
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  13. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
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  14. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
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  15. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
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  16. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
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  17. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
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  18. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
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  19. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
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    December 2020
  20. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    >> Share

  21. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
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    November 2020
  22. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    >> Share

  23. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
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  24. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
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    October 2020
  25. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
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  26. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
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  27. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    >> Share

  28. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    >> Share

    September 2020
  29. MORI T, Koyama N, Yokoo T, Segawa T, et al
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
    J Biol Chem. 2020 Sep 10. pii: RA119.012330. doi: 10.1074/jbc.RA119.012330.
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  30. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
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    August 2020
  31. SHIMONAKA S, Matsumoto SE, Elahi M, Ishiguro K, et al
    Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
    J Biol Chem. 2020 Aug 5. pii: RA120.013271. doi: 10.1074/jbc.RA120.013271.
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    July 2020
  32. KATSIKOUDI A, Ficulle E, Cavallini A, Sharman G, et al
    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
    J Biol Chem. 2020 Jul 22. pii: RA120.013325. doi: 10.1074/jbc.RA120.013325.
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  33. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
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  34. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    >> Share

  35. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
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    June 2020
  36. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
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    May 2020
  37. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
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  38. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
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  39. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
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    April 2020
  40. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
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    March 2020
  41. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    >> Share

  42. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
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    January 2020
  43. XIAO Y, Matsuda I, Inoue M, Sasahara T, et al
    NMR-based site-resolved profiling of beta-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.
    J Biol Chem. 2020;295:458-467.
    >> Share

    September 2019
  44. SEIDLER PM, Boyer DR, Murray KA, Yang TP, et al
    Structure-based inhibitors halt prion-like seeding by Alzheimer's disease- and tauopathy-derived brain tissue samples.
    J Biol Chem. 2019 Sep 19. pii: RA119.009688. doi: 10.1074/jbc.RA119.009688.
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  45. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
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    August 2019
  46. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
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    July 2019
  47. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
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  48. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
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  49. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
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    June 2019
  50. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
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    May 2019
  51. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
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  52. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
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  53. LIU S, Ando F, Fujita Y, Liu J, et al
    A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice.
    J Biol Chem. 2019 May 9. pii: RA118.006420. doi: 10.1074/jbc.RA118.006420.
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    April 2019
  54. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
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    February 2019
  55. MICHNO W, Nystrom S, Wehrli P, Lashley T, et al
    Pyroglutamation of amyloid-betax-42 (Abetax-42) followed by Abeta1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.
    J Biol Chem. 2019 Feb 27. pii: RA118.006604. doi: 10.1074/jbc.RA118.006604.
    >> Share

  56. SMITH LM, Kostylev MA, Lee S, Strittmatter SM, et al
    Systematic and standardized comparison of reported Amyloid-beta receptors for sufficiency, affinity, and Alzheimer's disease relevance.
    J Biol Chem. 2019 Feb 20. pii: RA118.006252. doi: 10.1074/jbc.RA118.006252.
    >> Share

  57. JEAN L, Brimijoin S, Vaux DJ
    In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease.
    J Biol Chem. 2019 Feb 20. pii: RA118.006230. doi: 10.1074/jbc.RA118.006230.
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  58. TANG TC, Kienlen-Campard P, Hu Y, Perrin F, et al
    Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and gamma-secretase processing of the C99 peptide.
    J Biol Chem. 2019 Feb 12. pii: RA118.006061. doi: 10.1074/jbc.RA118.006061.
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    January 2019
  59. ANDREW RJ, De Rossi P, Nguyen P, Kowalski HR, et al
    Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
    J Biol Chem. 2019 Jan 28. pii: RA118.006379. doi: 10.1074/jbc.RA118.006379.
    >> Share

  60. HUR WS, Mazinani N, Lu XJD, Yefet LS, et al
    Coagulation factor XIIIa cross-links amyloid beta into dimers and oligomers and to blood proteins.
    J Biol Chem. 2019;294:390-396.
    >> Share

    December 2018
  61. MORI T, Koyama N, Tan J, Segawa T, et al
    Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
    J Biol Chem. 2018 Dec 18. pii: RA118.004280. doi: 10.1074/jbc.RA118.004280.
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    November 2018
  62. WEISMILLER HA, Murphy R, Wei G, Ma B, et al
    Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms.
    J Biol Chem. 2018;293:17336-17348.
    >> Share

    October 2018
  63. SADLEIR KR, Popovic J, Vassar R
    ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
    J Biol Chem. 2018 Oct 12. pii: RA118.005769. doi: 10.1074/jbc.RA118.005769.
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    August 2018
  64. DUNYS J, Valverde A, Checler F
    Are N- and C-terminally Truncated Abeta species key pathological triggers in Alzheimer's disease?
    J Biol Chem. 2018 Aug 24. pii: R118.003999. doi: 10.1074/jbc.R118.003999.
    >> Share

  65. EMENDATO A, Milordini G, Zacco E, Sicorello A, et al
    Glycation affects fibril formation of Abeta peptides.
    J Biol Chem. 2018;293:13100-13111.
    >> Share

  66. DODD RB
    An exTREMe disruption in Alzheimer's cleanup.
    J Biol Chem. 2018;293:12647-12648.
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    July 2018
  67. SANKAR SB, Donegan RK, Shah KJ, Reddi AR, et al
    Heme and hemoglobin suppress amyloid beta-mediated inflammatory activation of mouse astrocytes.
    J Biol Chem. 2018;293:11358-11373.
    >> Share

  68. GRIGNASCHI E, Cereghetti G, Grigolato F, Kopp MRG, et al
    A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
    J Biol Chem. 2018;293:11424-11432.
    >> Share

    June 2018
  69. YOUNAN ND, Chen KF, Rose RS, Crowther DC, et al
    Prion protein stabilizes amyloid-beta (Abeta) oligomers and enhances Abeta neurotoxicity in a Drosophila model of Alzheimer disease.
    J Biol Chem. 2018 Jun 10. pii: RA118.003319. doi: 10.1074/jbc.RA118.003319.
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    May 2018
  70. BISHOF I, Dammer EB, Duong DM, Kundinger S, et al
    RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
    J Biol Chem. 2018 May 25. pii: RA118.001747. doi: 10.1074/jbc.RA118.001747.
    >> Share

  71. SUDOM A, Talreja S, Danao J, Bragg E, et al
    Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
    J Biol Chem. 2018 May 24. pii: RA118.002352. doi: 10.1074/jbc.RA118.002352.
    >> Share

  72. TAYLOR IR, Ahmad A, Wu T, Nordhues BA, et al
    The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein.
    J Biol Chem. 2018 May 15. pii: RA118.002234. doi: 10.1074/jbc.RA118.002234.
    >> Share

  73. BAK LK, Walls AB, Schousboe A, Waagepetersen HS, et al
    Astrocytic glycogen metabolism in the healthy and diseased brain.
    J Biol Chem. 2018;293:7108-7116.
    >> Share

    April 2018
  74. MONDRAGON RODRIGUEZ S, Salas Gallardo A, Gonzalez Pereyra P, Macias M, et al
    Phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
    J Biol Chem. 2018 Apr 9. pii: RA117.001187. doi: 10.1074/jbc.RA117.001187.
    >> Share

    March 2018
  75. CHENG Q, Danao J, Talreja S, Wen P, et al
    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2(R47H) on murine myeloid cell function.
    J Biol Chem. 2018 Mar 29. pii: RA118.001848. doi: 10.1074/jbc.RA118.001848.
    >> Share

    January 2018
  76. HASHIMOTO S, Ishii A, Kamano N, Watamura N, et al
    Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm.
    J Biol Chem. 2018 Jan 3. pii: M117.811315. doi: 10.1074/jbc.M117.811315.
    >> Share

    December 2017
  77. GODOY MA, Saraiva LM, Carvalho LRP, Vasconcelos-Dos-Santos A, et al
    Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-beta oligomers.
    J Biol Chem. 2017 Dec 28. pii: M117.807180. doi: 10.1074/jbc.M117.807180.
    >> Share

  78. LAHIRI DK, Maloney B, Greig NH
    Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.
    J Biol Chem. 2017;292:20353.
    >> Share

    October 2017
  79. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    >> Share

  80. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    >> Share

    September 2017
  81. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    >> Share

    August 2017
  82. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    >> Share

    July 2017
  83. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    >> Share

  84. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    >> Share

    June 2017
  85. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    >> Share

  86. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    >> Share

  87. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    >> Share

    May 2017
  88. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.
    >> Share

  89. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    >> Share

  90. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    >> Share

  91. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    >> Share

  92. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    >> Share

    March 2017
  93. KORSHAVN KJ, Satriano C, Lin Y, Zhang R, et al
    Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-beta.
    J Biol Chem. 2017;292:4638-4650.
    >> Share

  94. GERBER H, Wu F, Dimitrov M, Garcia Osuna GM, et al
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production.
    J Biol Chem. 2017;292:3751-3767.
    >> Share

    February 2017
  95. MASON AR, Elia LP, Finkbeiner S
    The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    J Biol Chem. 2017;292:3262-3272.
    >> Share

  96. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross-interactions between the Alzheimer disease amyloid-beta peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS.
    J Biol Chem. 2017;292:2046.
    >> Share

  97. FENG T, Tammineni P, Agrawal C, Jeong YY, et al
    Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    J Biol Chem. 2017;292:1679-1690.
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    January 2017
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    Ion Channel Formation by Amyloid-beta42 Oligomers but Not Amyloid-beta40 in Cellular Membranes.
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  99. MERCER SW, Wang J, Burke R
    In vivo Modelling of the Pathogenic Effect of Copper Transporter Mutations that cause Menkes and Wilson Disease, Motor Neuropathy and Susceptibility to Alzheimer's Disease.
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  100. ANO Y, Dhata A, Taniguchi Y, Hoshi A, et al
    Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease.
    J Biol Chem. 2017 Jan 13. pii: jbc.M116.763813. doi: 10.1074/jbc.M116.763813.
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  101. HATAMI A, Monjazeb S, Milton S, Glabe CG, et al
    Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.
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    December 2016
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    Phosphorylation at Ser 8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue beta-Amyloid (Abeta40) Fibrils.
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    August 2016
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    Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
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    June 2016
  104. POLANCO JC, Scicluna BJ, Hill AF, Gotz J, et al
    Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
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  105. DELGADO DA, Doherty K, Cheng Q, Kim H, et al
    Distinct Membrane Disruption Pathways Are Induced by 40-Residue beta-Amyloid Peptides.
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  106. CIFELLI JL, Dozier L, Chung TS, Patrick GN, et al
    Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons.
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    April 2016
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    The Luminescent Oligothiophene p-FTAA Converts Toxic Abeta1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.
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