Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis. Yu H, Zhou Q, Chen Y, Zhong C, et al. J Biol Chem 2025;301:110575.

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Yu H, Zhou Q, Chen Y, Zhong C, et al. Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis. J Biol Chem 2025;301:110575.
PMID: 40784455