Amedeo's Top 20

Amedeo Smart

Independent Medical Education


19 March 2018

Multidisciplinary Journal Club

  1. McKeever T, Mortimer K, Wilson A, Walker S, et al.
    Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.
    N Engl J Med 2018;378:902-910.

  1. Jourdain G, Ngo-Giang-Huong N, Harrison L, Decker L, et al.
    Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B.
    N Engl J Med 2018;378:911-923.

  2. Harrison SA, Rinella ME, Abdelmalek MF, Trotter JF, et al.
    NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
    Lancet 2018.

  3. Durand CM, Bowring MG, Brown DM, Chattergoon MA, et al.
    Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus-Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial.
    Ann Intern Med 2018.

  4. Gunther G, van Leth F, Alexandru S, Altet N, et al.
    Clinical Management of Multidrug-resistant Tuberculosis in 16 European Countries.
    Am J Respir Crit Care Med 2018.

  1. Labhardt ND, Ringera I, Lejone TI, Klimkait T, et al.
    Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial.
    JAMA 2018.

  2. Kishan AU, Cook RR, Ciezki JP, Ross AE, et al.
    Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients With Gleason Score 9-10 Prostate Cancer.
    JAMA 2018;319:896-905.

  3. Martin RM, Donovan JL, Turner EL, Metcalfe C, et al.
    Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial.
    JAMA 2018;319:883-895.

  4. Chao TF, Liu CJ, Lin YJ, Chang SL, et al.
    Oral Anticoagulation in Very Elderly Patients with Atrial Fibrillation - A Nationwide Cohort Study.
    Circulation 2018.

  5. Krebs EE, Gravely A, Nugent S, Jensen AC, et al.
    Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.
    JAMA 2018;319:872-882.

  1. Wang S, Dos-Santos ALA, Huang W, Liu KC, et al.
    Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria.
    Science 2017;357:1399-1402.

  2. Brat GA, Agniel D, Beam A, Yorkgitis B, et al.
    Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study.
    BMJ 2018;360:j5790.

  3. Mottok A, Steidl C.
    Biology of classical Hodgkin lymphoma: implications for prognosis and novel therapies.
    Blood 2018.

  4. Lopes RD, Rordorf R, De Ferrari GM, Leonardi S, et al.
    Digoxin and Mortality in Patients With Atrial Fibrillation.
    J Am Coll Cardiol 2018;71:1063-1074.

  5. Clemente JC, Manasson J, Scher JU.
    The role of the gut microbiome in systemic inflammatory disease.
    BMJ 2018;360:j5145.

  1. Tremlett H, Zhu F, Ascherio A, Munger KL, et al.
    Sun exposure over the life course and associations with multiple sclerosis.
    Neurology 2018.

  2. Laharie D, Bourreille A, Branche J, Allez M, et al.
    Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab.
    Gut 2018;67:237-243.

  3. Pike A, Dong Y, Dizaji NB, Gacita A, et al.
    Changes in the microbiota cause genetically modified Anopheles to spread in a population.
    Science 2017;357:1396-1399.

  4. Brockelmann PJ, Sasse S, Engert A.
    Early-stage classical Hodgkin lymphoma.
    Blood 2018.

  5. Rusie LK, Orengo C, Burrell D, Ramachandran A, et al.
    PrEP Initiation and Retention in care over five years, 2012-2017: Are quarterly visits too much?
    Clin Infect Dis 2018.


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