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Articles published in
Proc Natl Acad Sci U S A
    April 2024
  1. WOO JR, Bae SH, Wales TE, Engen JR, et al
    The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction.
    Proc Natl Acad Sci U S A. 2024;121:e2401716121.
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  2. SHAO S, Zhang N, Specht GP, You S, et al
    Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair.
    Proc Natl Acad Sci U S A. 2024;121:e2400077121.
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    March 2024
  3. TASSOULAS LJ, Rankin JA, Elias MH, Wackett LP, et al
    Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes.
    Proc Natl Acad Sci U S A. 2024;121:e2312652121.
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    February 2024
  4. KULAK K, Kuska K, Colineau L, Mckay M, et al
    Intracellular C3 protects beta-cells from IL-1beta-driven cytotoxicity via interaction with Fyn-related kinase.
    Proc Natl Acad Sci U S A. 2024;121:e2312621121.
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  5. SELCK C, Jhala G, De George DJ, Kwong CJ, et al
    Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes.
    Proc Natl Acad Sci U S A. 2024;121:e2315419121.
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    January 2024
  6. LI Q, Tangry V, Allen DP, Seibert KD, et al
    Surface-mediated spontaneous emulsification of the acylated peptide, semaglutide.
    Proc Natl Acad Sci U S A. 2024;121:e2305770121.
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    December 2023
  7. DUTTA DJ, Sasaki J, Bansal A, Sugai K, et al
    Alternative splicing events as peripheral biomarkers for motor learning deficit caused by adverse prenatal environments.
    Proc Natl Acad Sci U S A. 2023;120:e2304074120.
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  8. YE C, Clements SA, Gu W, Geurts AM, et al
    Deletion of Vbeta3(+)CD4(+) T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8(+) T cells.
    Proc Natl Acad Sci U S A. 2023;120:e2312039120.
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    November 2023
  9. ZHONG X, Moresco JJ, Keller K, Lazaro DR, et al
    Essential requirement for IER3IP1 in B cell development.
    Proc Natl Acad Sci U S A. 2023;120:e2312810120.
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  10. PFEIFER CW, Walsh JT, Santeford A, Lin JB, et al
    Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
    Proc Natl Acad Sci U S A. 2023;120:e2308214120.
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    September 2023
  11. GAN T, Wang D
    Picobirnaviruses encode proteins that are functional bacterial lysins.
    Proc Natl Acad Sci U S A. 2023;120:e2309647120.
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    August 2023
  12. HUDAIBERDIEV S, Taylor DL, Song W, Narisu N, et al
    Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.
    Proc Natl Acad Sci U S A. 2023;120:e2206612120.
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  13. EISENBEIS VB, Qiu D, Gorka O, Strotmann L, et al
    beta-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner.
    Proc Natl Acad Sci U S A. 2023;120:e2306868120.
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  14. ADAM RC, Pryce DS, Lee JS, Zhao Y, et al
    Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.
    Proc Natl Acad Sci U S A. 2023;120:e2309967120.
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  15. HIRAIKE Y, Saito K, Oguchi M, Wada T, et al
    NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis.
    Proc Natl Acad Sci U S A. 2023;120:e2308750120.
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    July 2023

  16. Correction to Supporting Information for Girdhar et al., A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.
    Proc Natl Acad Sci U S A. 2023;120:e2309963120.
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  17. MOLLER LLV, Ali MS, Davey J, Raun SH, et al
    The Rho guanine dissociation inhibitor alpha inhibits skeletal muscle Rac1 activity and insulin action.
    Proc Natl Acad Sci U S A. 2023;120:e2211041120.
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    June 2023
  18. LOUZADA RA, Blandino-Rosano M, Flores S, Lubaczeuski C, et al
    GRHR agonist MR-409 protects beta-cells from streptozotocin-induced diabetes.
    Proc Natl Acad Sci U S A. 2023;120:e2209810120.
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  19. XUE Y, Cui A, Wei S, Ma F, et al
    Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism.
    Proc Natl Acad Sci U S A. 2023;120:e2219419120.
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    May 2023
  20. CHEN W, Huang Q, Lazdon EK, Gomes A, et al
    Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2220684120.
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  21. C LUU J, Saadane A, Leinonen H, H Choi E, et al
    Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
    Proc Natl Acad Sci U S A. 2023;120:e2221045120.
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  22. WANG A, Jing Y, Cheng Q, Zhou H, et al
    Loss of function of SSIIIa and SSIIIb coordinately confers high RS content in cooked rice.
    Proc Natl Acad Sci U S A. 2023;120:e2220622120.
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    April 2023
  23. SONG Y, Bell DR, Ahmed R, Chan KC, et al
    A mutagenesis study of autoantigen optimization for potential T1D vaccine design.
    Proc Natl Acad Sci U S A. 2023;120:e2214430120.
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  24. POZO M, Mila-Guasch M, Haddad-Tovolli R, Boudjadja MB, et al
    Negative energy balance hinders prosocial helping behavior.
    Proc Natl Acad Sci U S A. 2023;120:e2218142120.
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    March 2023
  25. LIANG W, Huang L, Whelchel A, Yuan T, et al
    Peroxisome proliferator-activated receptor-alpha (PPARalpha) regulates wound healing and mitochondrial metabolism in the cornea.
    Proc Natl Acad Sci U S A. 2023;120:e2217576120.
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  26. FERRIS ST, Liu T, Chen J, Ohara RA, et al
    WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis.
    Proc Natl Acad Sci U S A. 2023;120:e2219956120.
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  27. Correction for Taylor et al., Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
    Proc Natl Acad Sci U S A. 2023;120:e2302726120.
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    February 2023
  28. TAYLOR HJ, Hung YH, Narisu N, Erdos MR, et al
    Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
    Proc Natl Acad Sci U S A. 2023;120:e2206797120.
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    January 2023
  29. TOBAR N, Rocha GZ, Santos A, Guadagnini D, et al
    Metformin acts in the gut and induces gut-liver crosstalk.
    Proc Natl Acad Sci U S A. 2023;120:e2211933120.
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  30. SONG W, Postoak JL, Yang G, Guo X, et al
    Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.
    Proc Natl Acad Sci U S A. 2023;120:e2214874120.
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  31. MEDA VENKATA SP, Li H, Xu L, Koh JY, et al
    Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
    Proc Natl Acad Sci U S A. 2023;120:e2208541120.
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    December 2022
  32. NEMETCHEK MD, Chrisman IM, Rayl ML, Voss AH, et al
    A structural mechanism of nuclear receptor biased agonism.
    Proc Natl Acad Sci U S A. 2022;119:e2215333119.
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  33. LEE HY, Jang HR, Li H, Samuel VT, et al
    Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice.
    Proc Natl Acad Sci U S A. 2022;119:e2213628119.
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    November 2022
  34. RUBIN DE CELIS MF, Garcia-Martin R, Syed I, Lee J, et al
    PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.
    Proc Natl Acad Sci U S A. 2022;119:e2206923119.
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  35. YANG J, Zhen J, Feng W, Fan Z, et al
    IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of beta cells.
    Proc Natl Acad Sci U S A. 2022;119:e2204443119.
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    October 2022
  36. NIES VJM, Struik D, Liu S, Liu W, et al
    Autocrine FGF1 signaling promotes glucose uptake in adipocytes.
    Proc Natl Acad Sci U S A. 2022;119:e2122382119.
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  37. DU Q, Wu J, Fischer C, Seki T, et al
    Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo.
    Proc Natl Acad Sci U S A. 2022;119:e2203307119.
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    August 2022
  38. GIRDHAR K, Huang Q, Chow IT, Vatanen T, et al
    A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.
    Proc Natl Acad Sci U S A. 2022;119:e2120028119.
    >> Share

    June 2022
  39. GOLEC E, Ekstrom A, Noga M, Omar-Hmeadi M, et al
    Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets.
    Proc Natl Acad Sci U S A. 2022;119:e2120083119.
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    April 2022
  40. BELAVGENI A, Maremonti F, Stadtmuller M, Bornstein SR, et al
    Schwann cell necroptosis in diabetic neuropathy.
    Proc Natl Acad Sci U S A. 2022;119:e2204049119.
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  41. POSTIGO-FERNANDEZ J, Firdessa-Fite R, Creusot RJ
    Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2022;119:e2110987119.
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  42. GUO J, Guo Z, Huang Y, Ma S, et al
    Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy.
    Proc Natl Acad Sci U S A. 2022;119:e2121552119.
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  43. MADRIGAL-MATUTE J, de Bruijn J, van Kuijk K, Riascos-Bernal DF, et al
    Protective role of chaperone-mediated autophagy against atherosclerosis.
    Proc Natl Acad Sci U S A. 2022;119:e2121133119.
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    March 2022
  44. SUN B, Willard FS, Feng D, Alsina-Fernandez J, et al
    Structural determinants of dual incretin receptor agonism by tirzepatide.
    Proc Natl Acad Sci U S A. 2022;119:e2116506119.
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  45. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
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  46. ZHENG X, Ho QWC, Chua M, Stelmashenko O, et al
    Destabilization of beta Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
    Proc Natl Acad Sci U S A. 2022;119:e2113074119.
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    February 2022
  47. QIAO J, Zhang Z, Ji S, Liu T, et al
    A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119.
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    December 2021
  48. MILLS SA, Jobling AI, Dixon MA, Bui BV, et al
    Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy.
    Proc Natl Acad Sci U S A. 2021;118.
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    November 2021
  49. FORAY AP, Candon S, Hildebrand S, Marquet C, et al
    De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
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  50. YAHIL S, Wozniak DF, Yan Z, Mennerick S, et al
    Cognitive deficits and impaired hippocampal long-term potentiation in KATP-induced DEND syndrome.
    Proc Natl Acad Sci U S A. 2021;118.
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  51. VON HERRATH M, Bonifacio E
    How benign autoimmunity becomes detrimental in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
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    October 2021
  52. ANDERSON AM, Landry LG, Alkanani AA, Pyle L, et al
    Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
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  53. RAMIREZ DG, Ciccaglione M, Upadhyay AK, Pham VT, et al
    Detecting insulitis in type 1 diabetes with ultrasound phase-change contrast agents.
    Proc Natl Acad Sci U S A. 2021;118.
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    September 2021
  54. YANG K, O'Cearbhaill ED, Liu SS, Zhou A, et al
    A therapeutic convection-enhanced macroencapsulation device for enhancing beta cell viability and insulin secretion.
    Proc Natl Acad Sci U S A. 2021;118.
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    March 2021
  55. CAI S, Li H, Zheng F, Kong F, et al
    Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share


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